Azt Pricing Decision Essay Example for Free

Azt Pricing Decision Essay In 1986, Burroughs-Wellcome Company introduced the first major breakthrough against acquired immune deficiency syndrome (AIDS). It was the life-prolonging drug AZT. The product has turned out to be very successful for the company and, largely because of AZT’s success, Burroughs-Wellcome’s profits have doubled in the three years ending in 1988. The Food and Drug Administration (FDA) plans to expand the authorization for the drug’s usage to those who are infected with the AIDS virus, but not yet showing signs of serious illness. The estimate of the size of this market is hundreds of thousands rather than the tens of thousand who are currently sick with AIDS (1988). The controversy over the drug centers on its price. AZT costs about $8,600 for a year’s supply for each patient (lowered from $10,000 in 1987). Critics in the gay, medical, and legal communities contend that Burroughs-Wellcome executives are â€Å"corporate extortionists.† Some believe that the company has already made too much money at the expense of the sick. The price is so far out of reach of indigent and moderate-income people that the federal government had to step in with subsidies of millions of dollars. Burroughs-Wellcome defends it pricing practices by stating that its profit margins (in the 50-70 percent range) are in line with those companies introducing new drugs. They contend these high returns are necessary to finance research and recoup the millions of dollars invested in developing the drug. They initially gave the drug free-of-charge to as many as 5,000 AIDS patients and spent $80 million on a new plant. Additional criticism revolves around the actual development of the drug. The Wall Street Journal stated, â€Å"But Wellcome’s moral position is undercut by its relatively minor role in the creation of AZT.† Researchers at the Michigan Cancer Foundation, from West Germany, and at the National Cancer Institute are credited with the major discoveries that led to AZT. Nevertheless, Wellcome performed toxicology, pharmacology, and animal studies before AZT was given to the first human volunteer. It also financed the big clinical trial and bankrolled the give-away to the patients in the initial experiment. Wellcome is under pressure to cut its price. The government is attempting to institute a â€Å"reasonable price† clause where an unduly high price could trigger a government order for a company to open its books. Any company found in violation could be sued for breach of contract. Congress is also studying AZT and one Congressman wrote the company contending that the original price rationale (achieving a decent return on investment during a short product life) no longer exists as the drug has been on the market for three years and the market is growing for the product.

Modernism and New Criticism Essay -- Modernism New Criticism Literatur

Modernism and New Criticism The ways in which we define the importance of texts is constantly changing. We can look back and see critical theories used, such as Historical Criticism, Reader-Response Criticism and Psychoanalytic Criticism. Each of these theories offers a different way to interpret a text. However, when looking back over the texts of a specific era, shouldn’t the type of criticism we used for a book be based on that time period? Defining the Modernist Era of literature seems almost impossible, since the definition of modernism often seems to constitute anything from being â€Å"new and common† to â€Å"new and uncommon† (Barzun). This term seems to be able to stretch from the 1500’s to present; but for the sake of this essay the Modernist Era in question is that from the early twentieth century (circa 1910-1940’s). Out of, and during, this era the critical theory named New Criticism came into play. Although, nowadays, the use of New Criticism is unpopular, it is essential to use when defining the Modernist Era. Even though New Criticism isn’t used anymore, many of its basic constructs are. For example, the idea of close reading and using textual evidence (as will be done in this essay) are characteristics that were important to New Criticism. Now it is practically impossible to be in an English class, be it high school or college, and not have to use these skills when talking about a text. New Criticism basically theorized that the text itself was the most important aspect of writing; therefore, to understand the meaning of a piece of literature one must look to, and in, the text, rather than trying to define it by outside components, such as those used in Historical and Biographical Criti... ...120). The text itself is one we can always count on and find meaning in, since it always there, unchanging. Work Cited Barzun, Jacques. â€Å"The Artist as Prophet and Jester†. The American Scholar. 69.1 (Winter 2000): 15-33. Bressler, Charles E. Literary Criticism. New Jersey: Pearson Education Inc., 2003. Eliot, TS. â€Å"The Waste Land†. The Norton Anthology of Modern and Contemporary Poetry. Ed. Jahan Ramazani. New York: Norton, 2003. 472-487. Eliot, TS. â€Å"Tradition and the Individual Talent†. The Sacred Wood. London: Methune, 1920. http://www.bartleby.com/200/sw4.html Faulkner, William. Light in August. New York: Vintage Books, 1932. Thody, Philip. Twentieth-Century Literature: Critical Issues and Themes. New York: St. Martin’s Press, 1996. Tyson, Lois. Critical Theory Today. New York: Garland Publishing Inc., 1999. 117-152.

Dunkirk Was a Miracle of Deliverance Essay

From the 27th of May to the 4th of June, there were the nine days of evacuation of British, French, Belgian and Dutch soldiers alike. They were trapped in the small town of Dunkirk due to the port that was there. After waiting for days, the majority were eventually rescued by a combination of naval vessels and civilian boats as well as fishing boats and ferries. It is regarded as a great victory for the British as it saved many lives although a military victory for the Germans. I agree with the quotation above that â€Å"Dunkirk was a miracle of deliverance† because of the overwhelming evidence of the pros of the operation (codenamed Operation Dynamo). The first pro of the evacuation was that 338,226 soldiers were rescued in the operation itself. Much of the British expeditionary force (BEF) was also rescued as well as 139,997 French soldiers. The German causalities were also very high with 27,074 killed and 111,034 wounded soldiers. Although there were many material losses, the morale of the British was raised after the evacuation of Dunkirk, as they felt that they were helping in the war effort and that even though many had died, many lived to â€Å"fight another day†. Another pro is that after Dunkirk the Americans were more motivated to enter the war and help the allies. On the other hand I disagree with this quotation because even with the rescuing of 338,226 men, another 68,000 British soldiers were killed and 290,000 French soldiers. Nearly all of Britain’s tanks, planes, naval vessels, small arms and motor vehicles were either damaged or left behind on the beaches of France. Another point for the cons is that many civilians were injured and killed whilst trying to rescue the soldiers stranded on the beaches. All in all Dunkirk was one of the greatest military victories for the Germans due to the massive loss of British soldiers and military resources. To conclude, although this was a great military victory for the Germans, it was also a great help in raising the hope of the British population. In short I agree with the quotation above because of the points stated above as well as the fact that if Dunkirk had failed in the slightest for the British then Churchill would have probably signed a peace treaty with Hitler, allowing the Germans to win the war. In the long-term, Dunkirk was a great victory for the British although it was a very big defeat in the short-term as much military strength was lost.

Introduction to the Dirac Delta Function

The Dirac delta function is the name given to a mathematical structure that is intended to represent an idealized point object, such as a point mass or point charge. It has broad applications within quantum mechanics and the rest of quantum physics, as it is usually used within the quantum wavefunction. The delta function is represented with the Greek lowercase symbol delta, written as a function: ÃŽ ´(x). How the Delta Function Works This representation is achieved by defining the Dirac delta function so that it has a value of 0 everywhere except at the input value of 0. At that point, it represents a spike that is infinitely high.  The integral taken over the entire line is equal to 1. If youve studied calculus, youve likely run into this phenomenon before. Keep in mind that this is a concept that is normally introduced to students after years of college-level study in theoretical physics. In other words, the results are the following for the most basic delta function ÃŽ ´(x), with a one-dimensional variable x, for some random input values: ÃŽ ´(5) 0ÃŽ ´(-20) 0ÃŽ ´(38.4) 0ÃŽ ´(-12.2) 0ÃŽ ´(0.11) 0ÃŽ ´(0) ∞ You can scale the function up by multiplying it by a constant. Under the rules of calculus, multiplying by a constant value will also increase the value of the integral by that constant factor. Since the integral of ÃŽ ´(x) across all real numbers is 1, then multiplying it by a constant of would have a new integral equal to that constant. So, for example, 27ÃŽ ´(x) has an integral across all real numbers of 27. Another useful thing to consider is that since the function has a non-zero value only for an input of 0, then if youre looking at a coordinate grid where your point isnt lined up right at 0, this can be represented with an expression inside the function input. So if you want to represent the idea that the particle is at a position x 5, then you would write the Dirac delta function as ÃŽ ´(x - 5) ∞ [since ÃŽ ´(5 - 5) ∞].   If you then want to use this function to represent a series of point particles within a quantum system, you can do it by adding together various dirac delta functions. For a concrete example, a function with points at x 5 and x 8 could be represented as ÃŽ ´(x - 5) ÃŽ ´(x - 8). If you then took an integral of this function over all numbers, you would get an integral that represents real numbers, even though the functions are 0 at all locations other than the two where there are points. This concept can then be expanded to represent a space with two or three dimensions (instead of the one-dimensional case I used in my examples). This is an admittedly-brief introduction to a very complex topic. The key thing to realize about it is that the Dirac delta function basically exists for the sole purpose of making the integration of the function make sense. When there is no integral taking place, the presence of the Dirac delta function isnt particularly helpful. But in physics, when you are dealing with going from a region with no particles that suddenly exist at only one point, its quite helpful. Source of the Delta Function In his 1930 book, Principles of Quantum Mechanics, English theoretical physicist Paul Dirac laid out the key elements of quantum mechanics, including the bra-ket notation and also his Dirac delta function. These became standard concepts in the field of quantum mechanics within the Schrodinger equation.